Skip to Content
MilliporeSigma

Skip To

SML3499

Sigma-Aldrich

LM10

≥98% (HPLC)

Synonym(s):

(E)-3-(2-(1H-tetrazol-5-yl)vinyl)-6-fluoro-1H-indole, 6-Fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]-1H-indole, LM 10, trans-6-Fluoro-3-(2-(1H-tetrazol-5-yl)vinyl)-1H-indole

Sign Into View Organizational & Contract Pricing

About This Item

Empirical Formula (Hill Notation):
C11H8FN5
CAS Number:
Molecular Weight:
229.21
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC1=CC2=C(C=C1)C(/C=C/C3=NN=NN3)=CN2

InChI

1S/C11H8FN5/c12-8-2-3-9-7(6-13-10(9)5-8)1-4-11-14-16-17-15-11/h1-6,13H,(H,14,15,16,17)/b4-1+

InChI key

JDBSZVDIUIRSDG-DAFODLJHSA-N

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
SML3455SML0287SML3126
LM10 ≥98% (HPLC)

SML3499

LM10

680C91 ≥98% (HPLC)

SML0287

680C91

BI-2852 ≥98% (HPLC)

SML3126

BI-2852

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: ≥10 mg/mL

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

LM10 is an orally available, aqueous soluble, potent, selective and non-toxic tryptophan 2,3-dioxygenase (TDO) inhibitor. LM10 diminishes tryptophan degradation and effectively prevents the growth of TDO-expressing P815 tumor cells by reversing immune resistance in immune competent but not in immunodeficient mice (at a dose of 4 mg/day, 1 mg/ml in water, pH 9.0). LM10 suppresses autoimmune reactions induced by mouse hepatitis virus in mice.
Orally available, potent and selective tryptophan 2,3-dioxygenase (TDO) inhibitor

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


  • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number

    It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

    If you need assistance, please contact Customer Support

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service