901494

N-Methylated pomalidomide

≥98%

• Synonyme(s) : 4-Amino-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione, E3 Ligase ligand methylated negative control, Ligand for PROTAC^® research
• Formule empirique (notation de Hill) : C₁₄H₁₃N₃O₄
• CAS Number: 1352827-50-9
• Poids moléculaire : 287.27
• Numéro MDL: MFCD31703382
• Code UNSPSC : 12352101
• Nomenclature NACRES : NA.22

Propriétés

• ligand: N-Methylated Pomalidomide
• Niveau de qualité: 100
• Essai: ≥98%
• Forme: powder or crystals
• Pertinence de la réaction: reagent type: ligand
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3N)=O)N(C)C1=O
• InChI: 1S/C14H13N3O4/c1-16-10(18)6-5-9(13(16)20)17-12(19)7-3-2-4-8(15)11(7)14(17)21/h2-4,9H,5-6,15H2,1H3
• Clé InChI: YSWQOCGODHPKED-UHFFFAOYSA-N

Description

Application

N-Methylated pomalidomide is a ligand used as a negative control for pomalidomide (P0018) in the recruitment of the Cereblon (CRBN) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.

Autres remarques

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable