P0018

Pomalidomide

≥98% (HPLC), powder, HbF inducer

• Synonyme(s) : 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline, 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide, 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, Actimid, CC-4047, IMiD 3
• Formule empirique (notation de Hill) : C₁₃H₁₁N₃O₄
• CAS Number: 19171-19-8
• Poids moléculaire : 273.24
• Numéro MDL: MFCD12756407
• Code UNSPSC : 12352200
• ID de substance PubChem : 329819974
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Pomalidomide, ≥98% (HPLC)
• ligand: pomalidomide
• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Pertinence de la réaction: reagent type: ligand
• Couleur: yellow
• Solubilité: DMSO: ≥14 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
• InChI: 1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
• Clé InChI: UVSMNLNDYGZFPF-UHFFFAOYSA-N
• Informations sur le gène: human ... CRBN(51185), CUL4A(8451), DDB1(1642), RBX1(9978)

Description

Application

Pomalidomide has been used:

• to treat BV173 cells to study the role of proteolysis targeting chimera (PROTAC) compound, JQ1-CRBN, in inducing specific class-I major histocompatibility complex (MHC-I) peptides
• for apoptosis studies and intracellular calcium analysis
• as a fetal hemoglobin (HbF) agent to study the additive effect with UNC0638 on the levels of fetal hemoglobin expression in β-thalassemia/ variant hemoglobin E (HbE) erythroid progenitor cells

Actions biochimiques/physiologiques

Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog.

Pomalidomide is an effective fetal hemoglobin (HbF) inducer that downregulates the key &#947-globin repressors, SRY-box transcription factor 6 (SOX6), and BAF chromatin remodeling complex subunit (BCL11A).

Caractéristiques et avantages

This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H360D
• Conseils de prudence: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable