907367

Fmoc-L-photo-methionine

≥95%, for peptide synthesis

• Synonyme(s) : (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-4-(3-methyl-3H-diazirin-3-yl)butanoic acid, (S)-2-(Fmoc-amino)-4-(3H-diazirin-3-yl)pentanoic acid, Diazirine amino acid, Photo-Met, Photo-crosslinking amino acid, Photoprobe building block
• Formule empirique (notation de Hill) : C₂₁H₂₁N₃O₄
• CAS Number: 945859-89-2
• Poids moléculaire : 379.41
• Numéro MDL: MFCD31380717
• Code UNSPSC : 12352209
• Nomenclature NACRES : NA.22

Propriétés

• Product Name: Fmoc-L-photo-methionine, ≥95%
• Essai: ≥95%
• Forme: powder
• Capacité de réaction: reaction type: Fmoc solid-phase peptide synthesis
• Application(s): peptide synthesis
• Groupe fonctionnel: Fmoc
• Température de stockage: −20°C
• Chaîne SMILES: N([C@@H](CCC4(N=N4)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3
• Clé InChI: QKMQUEIDJLPYHS-SFHVURJKSA-N

Description

Application

Fmoc-L-photo-methionine is a diazirine-containing, Fmoc-protected methionine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (∼360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907375.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

Autres remarques

Developing diazirine-based chemical probes to identify histone modification ′readers′ and ′erasers ′

Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe

Covalent Capture of Phospho-Dependent Protein Oligomerization by Site-Specific Incorporation of a Diazirine Photo-Cross-Linker

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable