361515

Glycogen Phosphorylase Inhibitor

The Glycogen Phosphorylase Inhibitor, also referenced under CAS 648926-15-2, controls the biological activity of Glycogen Phosphorylase.

• Synonyme(s) : Glycogen Phosphorylase Inhibitor, 1-(3-(3-(2-Chloro-4,5-difluorobenzoyl)ureido)-4-methoxyphenyl)-3-methylurea
• Formule empirique (notation de Hill) : C₁₇H₁₅ClF₂N₄O₄
• CAS Number: 648926-15-2
• Poids moléculaire : 412.78
• Numéro MDL: MFCD22050364
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: DMSO: 25 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• Chaîne SMILES: Fc1c(cc(c(c1)Cl)C(=O)NC(=O)Nc2c(ccc(c2)NC(=O)NC)OC)F
• InChI: 1S/C17H15ClF2N4O4/c1-21-16(26)22-8-3-4-14(28-2)13(5-8)23-17(27)24-15(25)9-6-11(19)12(20)7-10(9)18/h3-7H,1-2H3,(H2,21,22,26)(H2,23,24,25,27)
• Clé InChI: ROJNYKZWTOHRNU-UHFFFAOYSA-N

Description

Description générale

A cell-permeable urea compound that acts as a potent and AMP-competitive inhibitor of glycogen phosphorylase (GP; IC₅₀ = 53 nM). Shown to inhibit glucagon-induced glyocgenolysis both in hepatocytes (IC₅₀ = 380 nM) in vitro and in rats (5 mg/kg, iv) in vivo.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Glycogen phosphorylase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 53 nM against glycogen phosphorylase

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Klabunde, T., et al. 2005. J. Med. Chem.48, 6178

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable