475870

MnTBAP

≥95% (TLC), solid, SOD mimetic, Calbiochem^®

• Synonyme(s) : MnTBAP, Mn(III)tetrakis(4-benzoic acid)porphyrin Chloride
• Formule empirique (notation de Hill) : C₄₈H₂₈ClMnN₄O₈
• CAS Number: 55266-18-7
• Poids moléculaire : 879.15
• Numéro MDL: MFCD06227760
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: MnTBAP, Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.
• Niveau de qualité: 100
• Essai: ≥95% (TLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated; protect from light
• Couleur: brown
• Solubilité: aqueous base: soluble
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: [Mn]1([n]2c3c(c5nc(c(c7[n]1c(c(c9nc(c(c2cc3)c%10ccc(cc%10)C(=O)O)cc9)c8ccc(cc8)C(=O)O)cc7)c6ccc(cc6)C(=O)O)cc5)c4ccc(cc4)C(=O)O)Cl
• Clé InChI: XHVDAQLNUQLQKW-PTJHDCLZSA-K

Description

Description générale

Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC₅₀ ~40 µM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO).

Actions biochimiques/physiologiques

Cell permeable: yes

EC50 ~40 µM in protecting endothelial cells against paraquat (2 mM)

Primary Target
Superoxide dismutase (SOD) mimetic

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Aladag, M. A., et al. 2003. Acta Neurochir.145, 673.
Szabo, C., et al. 1996. FEBS Lett. 381, 82.
Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable