553211

Rapamycin

≥95% (HPLC), solution, mTOR inhibitor, Calbiochem

• Synonyme(s) : InSolution Rapamycin, mTOR Inhibitor I
• Formule empirique (notation de Hill) : C₅₁H₇₉NO₁₃
• Poids moléculaire : 914.17
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Rapamycin, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus
• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: solution
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: desiccated (hygroscopic); protect from light
• Conditions d'expédition: wet ice
• Température de stockage: −20°C

Description

Description générale

Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC₅₀ = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G₁ phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G₁ phase.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Mammalian target of rapamycin (mTOR)

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 50 pM inhibiting the mammalian target of rapamycin (mTOR) and blocking the subsequent activation of p70 S6 kinase

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Irritant (B)

Forme physique

2.5 mg/mL solution in DMSO (2.74 mM)

Reconstitution

Following initial use, aliquot and freeze (-20°C).

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Point d'éclair (°C): 87 °C - closed cup - (Dimethylsulfoxide)