17849

Enrofloxacin

≥99.0%

• Synonyme(s) : Baytril
• Formule empirique (notation de Hill) : C₁₉H₂₂FN₃O₃
• CAS Number: 93106-60-6
• Poids moléculaire : 359.39
• Beilstein: 5307824
• Numéro MDL: MFCD00792463
• Code UNSPSC : 41116105
• ID de substance PubChem : 329751571
• Nomenclature NACRES : NA.21

Propriétés

• Niveau de qualité: 200
• Essai: ≥99.0%; 99.0-101.0% (dried substance)
• Forme: powder or crystals
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria
• Mode d’action: DNA synthesis | interferes; enzyme | inhibits
• Chaîne SMILES: CCN1CCN(CC1)c2cc3N(C=C(C(O)=O)C(=O)c3cc2F)C4CC4
• InChI: 1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26)
• Clé InChI: SPFYMRJSYKOXGV-UHFFFAOYSA-N

Description

Description générale

Chemical structure: fluoroquinolone

Enrofloxacin is a veterinary fluoroquinolone (FQ) antibiotic with broad-spectrum antimicrobial activity. FQ drugs chelate to iron with high affinity. This chelation leads to inhibition of Fe(II)-dependent dioxygenases involved in the regulation of epigenetic control, collagen maturation, and HIF (hypoxia-inducible factor) degradation. The side effects associated with FQ drugs are renal toxicity and tendinopathy. Enrofloxacin is used in aquaculture and its use may cause an increase in the growth of antibiotic resistant microbes in an aquatic environment. The drug may have negative effects on public health and environment.

Application

Enrofloxacin has been used:

• to investigate the pathological mechanisms resulting from the toxicity of fluoroquinolones in mammalian cells
• to prepare a standard solution with 50% acetonitrile in a study to analyze illegal fish drugs used in aquaculture by employing surface-enhanced Raman spectroscopy (SERS)
• as an analyte in a chemiluminescence reagent system

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H317,H334
• Conseils de prudence: P261 - P264 - P270 - P280 - P301 + P312 - P302 + P352
• Classification des risques: Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)