27102

Acide citrique monohydrate

puriss., meets analytical specification of Ph. Eur., BP, USP, E330, 99.5-100.5% (based on anhydrous substance), grit

• Synonyme(s) : 2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate
• Formule linéaire : HOC(COOH)(CH₂COOH)₂ · H₂O
• CAS Number: 5949-29-1
• Poids moléculaire : 210.14
• Beilstein: 4018641
• Numéro CE : 201-069-1
• Numéro MDL: MFCD00149972
• Code UNSPSC : 12352100
• ID de substance PubChem : 57648219
• Nomenclature NACRES : NA.21

Propriétés

• Qualité: puriss.; meets analytical specification of Ph. Eur., BP, USP, E330
• Niveau de qualité: 200
• Essai: 99.5-100.5% (based on anhydrous substance)
• Forme: grit
• Impuretés: residual solvents, complies; ≤0.0005% heavy metals (as Pb); 7.5-8.8% water (Karl Fischer)
• Résidus de calcination: ≤0.05% (as SO₄)
• pKa: (1) 3.13, (2) 4.76, (3) 6.4
• Traces d'anions: chloride (Cl^-): ≤50 mg/kg; oxalate (as oxalic acid): ≤100 mg/kg; sulfate (SO₄^2-): ≤100 mg/kg
• Traces de cations: As: ≤1 mg/kg; Ca: ≤200 mg/kg; Cu: ≤10 mg/kg; Fe: ≤10 mg/kg; Hg: ≤1 mg/kg; Pb: ≤1 mg/kg; Zn: ≤10 mg/kg
• Adéquation: complies for appearance of solution; complies for identity (IR); complies for reaction against H₂SO₄
• Groupe fonctionnel: carboxylic acid
• Chaîne SMILES: OC(CC(O)(C(O)=O)CC(O)=O)=O.O
• InChI: 1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2
• Clé InChI: YASYEJJMZJALEJ-UHFFFAOYSA-N

Description

Description générale

Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be Δ_solH_m (298.15K, m = 0.0203molkg^-1) = (29061 ± 123)Jmol^-1

Application

Citric acid monohydrate may be used in the diltiazem hydrochloride (drug) and melt extruded Eudragit RS PO (polymer) formulations. It improves the solubility of drug in the polymer matrix. It may be used to prepare citrate buffer for use in the intravital microscopic studies of adhesion and aggregation of platelets.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 345.0 °F - closed cup
• Point d'éclair (°C): 173.9 °C - closed cup
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves