27602

Caféine

anhydrous, tested according to Ph. Eur.

• Synonyme(s) : 1,3,7-triméthylxanthine
• Formule empirique (notation de Hill) : C₈H₁₀N₄O₂
• CAS Number: 58-08-2
• Poids moléculaire : 194.19
• Beilstein: 17705
• Numéro CE : 200-362-1
• Numéro MDL: MFCD00005758
• Code UNSPSC : 12352210
• ID de substance PubChem : 329753004
• Nomenclature NACRES : NA.21

Propriétés

• Qualité: anhydrous
• Niveau de qualité: 100
• Agence: EPA 1694; USP/NF; tested according to Ph. Eur.
• Forme: powder
• Pf: 234-236.5 °C (lit.)
• Solubilité: H₂O: soluble 18.7 g/L at 16 °C
• Application(s): environmental
• Chaîne SMILES: CN1C(=O)N(C)c2ncn(C)c2C1=O
• InChI: 1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3
• Clé InChI: RYYVLZVUVIJVGH-UHFFFAOYSA-N
• Informations sur le gène: human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE4B(5142) ; mouse ... Adora2b(11541) ; rat ... Adora1(29290), Adora2a(25369)

Description

Application

Caffeine has been used as a radiosensitizing agent utilized for studying its impact in inhibiting the catalytic activity of ATM and ATR Kinase. CTGF is an important modulator protein of fibrogenic TGF-β. Hence, this product has also been used for examining the caffeine-dependent regulation of CTGF expression in rat hepatocytes.

Actions biochimiques/physiologiques

Caffeine is a central nervous system stimulant, adenosine receptor antagonist as well as adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. It stimulates the sarcoplasmic reticulum (SR) Ca²⁺-release channel which facilitates the excitation-contraction coupling in cardiac muscle. It has also been reported to affect cellular calcium levels, releasing calcium from intracellular stores. Caffeine overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves