M3501

8-Methoxypsoralen

analytical standard

• Synonyme(s) : 8-MOP, 9-Methoxyfuro[3,2-g][1]benzopyran-7-one, Ammoidin, Methoxsalen, Xanthotoxin
• Formule empirique (notation de Hill) : C₁₂H₈O₄
• CAS Number: 298-81-7
• Poids moléculaire : 216.19
• Beilstein: 196453
• Numéro CE : 206-066-9
• Numéro MDL: MFCD00005009
• Code UNSPSC : 41116107
• ID de substance PubChem : 24896845
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: analytical standard
• Niveau de qualité: 100
• Forme: crystals; fibers; powder
• Technique(s): HPLC: suitable; gas chromatography (GC): suitable
• Couleur: white to yellow
• Pf: 148-150 °C (lit.)
• Solubilité: H₂O: slightly soluble; acetic acid: soluble
• Application(s): food and beverages
• Format: neat
• Chaîne SMILES: COc1c2OC(=O)C=Cc2cc3ccoc13
• InChI: 1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3
• Clé InChI: QXKHYNVANLEOEG-UHFFFAOYSA-N
• Informations sur le gène: rat ... Maoa(29253)

Description

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Actions biochimiques/physiologiques

8-methoxypsoralen (8-MOP) plus ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms. Cultured normal human melanocytes treated with 8-methoxypsoralen and irradiated with ultraviolet A (UVA) formed 8-methoxypsoralen-phospholipid photoadducts that could be substituted for diacylglycerol to activate protein kinase C in a cell-free system. 8-MOP is an inactivator of purified reconstituted cytochrome P450. It also inhibits substance P-induced histamine release from substance P-activated rat peritoneal mast cells by suppressing the rise in [Ca²⁺].

Attention

Protect from light.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H317,H341,H351
• Conseils de prudence: P202 - P261 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Carc. 2 - Muta. 2 - Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves