P8399

Psoralen

≥99% (HPLC)

• Synonyme(s) : 6,7-Furanocoumarin, 7H-Furo[3,2-g]benzopyran-7-one, Ficusin, Furo[3,2-g]coumarin
• Formule empirique (notation de Hill) : C₁₁H₆O₃
• CAS Number: 66-97-7
• Poids moléculaire : 186.16
• Beilstein: 152784
• Numéro CE : 200-639-7
• Numéro MDL: MFCD00010520
• Code UNSPSC : 12352200
• ID de substance PubChem : 24898918
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: ≥99% (HPLC)
• Forme: powder
• Fluorescence: λ_ex 335 nm; λ_em 460 nm (pH 7.0)
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C1Oc2cc3occc3cc2C=C1
• InChI: 1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H
• Clé InChI: ZCCUUQDIBDJBTK-UHFFFAOYSA-N

Description

Application

Photochemical reagent for the investigation of nucleic acid structure and function.

Psoralen has been used:

• as a crosslinker for dsRNA for in- situ hybridization studies
• in testing melanin dispersal effects in fish scale melanophores
• to test its stimulatory effects in osteoblast a cell proliferation assay
• as a reference standard in high-performance liquid chromatography (HPLC)

Actions biochimiques/physiologiques

Psoralen belongs to the linear type furanocoumarins. It intercalates and induces interstrand cross-links in DNA. On UV exposure psoralen is excited leading to irreversible intercalation with DNA by covalent bond formation. This property of psoralen ultraviolet A light (PUVA) is exploited in treating skin diseases and cutaneous T-cell lymphoma. However, usage psoralen also leads to hepatotoxicity and cytotoxicity by the generation of psoralen photoproducts (POPs). It may be useful in treating osteoporosis

Caractéristiques et avantages

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Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H317
• Conseils de prudence: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Classification des risques: Acute Tox. 4 Oral - Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves