16758

Poly(éthylene glycol)-blocage-poly(propylène glycol)-blocage-poly(éthylene glycol)

purified, non-ionic

• Synonyme(s) : Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)
• CAS Number: 9003-11-6
• Numéro MDL: MFCD00082049
• Code UNSPSC : 12352104
• Nomenclature NACRES : NA.25

Propriétés

• Niveau de qualité: 100
• Forme: powder
• Qualité: purified
• Impuretés: ≤1.0% water
• pH: 5.0-7.5
• Solubilité: soluble, clear, colorless
• Traces de cations: Al: ≤5 mg/kg; As: ≤0.05 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤50 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤1000 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• Absorption UV: λ: 260 nm A_max: ≤0.3; λ: 280 nm A_max: ≤0..2
• Adéquation: no residue for filter test
• Température de stockage: 2-8°C
• Chaîne SMILES: O2C(C2)C.O1CC1
• InChI: 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
• Clé InChI: RVGRUAULSDPKGF-UHFFFAOYSA-N

Description

Description générale

Poloxamer 407 is a water-soluble, non-ionic surfactant with low toxicity and good solubilizing capacity. This triblock copolymer is composed of a hydrophobic residue of polyoxypropylene (POP) flanked by two hydrophilic units of polyoxyethylene (POE).

Application

Poloxamer 407 has been used:

• as an inhibitor of lipoprotein lipase activity to assess hepatic very-low-density lipoprotein (VLDL)- triglyceride (TG) secretion in mice
• for VLDL secretion assay in mice
• to intraperitoneally inject the mice by dissolving in phosphate buffer saline (PBS) for hepatic triglyceride production

Actions biochimiques/physiologiques

Poloxamer 407 (P407) exhibits reversible gelation properties above a particular polymer concentration and temperature. Poloxamer 407-based sterile injectable formulations serve to be a good candidate for drug delivery. P407 thermo-responsive hydrogels are broadly used as mucosal drug delivery systems as they do not irritate the mucosal membranes. P407 is called an “inactive ingredient” by the U.S. Food and Drug Administration (FDA) for several drug products like oral solutions, suspensions, and inhalation formulations.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)