47568

5-Fluoro-L-tryptophan

≥98.0% (HPLC)

• Formule empirique (notation de Hill) : C₁₁H₁₁FN₂O₂
• CAS Number: 16626-02-1
• Poids moléculaire : 222.22
• Beilstein: 5052680
• Numéro MDL: MFCD00066470
• Code UNSPSC : 12352202
• eCl@ss : 32160406
• ID de substance PubChem : 57651014
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98.0% (HPLC)
• Forme: powder
• Pureté optique: enantiomeric ratio: ≥99.5:0.5 (HPLC)
• Pf: 270-280 °C
• Température de stockage: 2-8°C
• Chaîne SMILES: N[C@@H](Cc1c[nH]c2ccc(F)cc12)C(O)=O
• InChI: 1S/C11H11FN2O2/c12-7-1-2-10-8(4-7)6(5-14-10)3-9(13)11(15)16/h1-2,4-5,9,14H,3,13H2,(H,15,16)/t9-/m0/s1
• Clé InChI: INPQIVHQSQUEAJ-VIFPVBQESA-N

Description

Application

Exogenous 5-fluoro-Trp is incorporated into proteins in normal protein synthesis. Since ¹⁹F is a useful reporter group, this provides a method for studying enzyme mechanisms by NMR.

Actions biochimiques/physiologiques

5-Fluoro-Trp is nonspecifically cytotoxic. It is believed this is due to malfunctioning enzymes that have had replacements of Trp residues by 5-fluoro-Trp. However, at least one case is known where 5-fluoro-Trp substitution leads to significantly greater catalytic activity.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)