A0384

Arcaine sulfate salt

• Synonyme(s) : 1,4-Diguanidinobutane sulfate salt
• Formule empirique (notation de Hill) : C₆H₁₆N₆ · H₂O₄S
• CAS Number: 14923-17-2
• Poids moléculaire : 270.31
• Numéro MDL: MFCD00050545
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277954
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Essai: ≥98% (TLC)
• Forme: powder
• Pf: >280 °C
• Solubilité: 1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Chaîne SMILES: OS(O)(=O)=O.NC(=N)NCCCCNC(N)=N
• InChI: 1S/C6H16N6.H2O4S/c7-5(8)11-3-1-2-4-12-6(9)10;1-5(2,3)4/h1-4H2,(H4,7,8,11)(H4,9,10,12);(H2,1,2,3,4)
• Clé InChI: RWTGFMPOODRXIM-UHFFFAOYSA-N
• Informations sur le gène: human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)

Description

Application

Arcaine sulfate salt has been used as an N-methyl-d-aspartate (NMDA) receptor effector/antagonist:

• to evaluate its effects on the acquisition of electrical kindling of the amygdala
• to compare its effects with agmatine and MK801 on NMDA- or glutamate-induced neuronal damage
• to study its effects on cell-free translation of synthetic polynucleotide

Actions biochimiques/physiologiques

Arcaine sulfate salt (1,4-diguanidinobutane), a polyamine, is an antagonist of the polyamine binding site of the N-methyl-d-aspartate (NMDA) receptor. Arcaine, an agmatine analog, along with ifenprodil, might have a possibility for therapeutic management in epileptic disorders.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)