A1221

AH6809

≥98%, crystalline solid or supercooled liquid

• Synonyme(s) : 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid
• Formule empirique (notation de Hill) : C₁₇H₁₄O₅
• CAS Number: 33458-93-4
• Poids moléculaire : 298.29
• Numéro MDL: MFCD08056083
• Code UNSPSC : 12352200
• ID de substance PubChem : 329770690
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98%
• Forme: crystalline solid or supercooled liquid
• Solubilité: ethanol: soluble 2.5 mg/mL; DMSO or DMF: soluble 8 mg/mL
• Chaîne SMILES: CC(C)Oc1ccc2c(Oc3ccc(cc3C2=O)C(O)=O)c1
• InChI: 1S/C17H14O5/c1-9(2)21-11-4-5-12-15(8-11)22-14-6-3-10(17(19)20)7-13(14)16(12)18/h3-9H,1-2H3,(H,19,20)
• Clé InChI: AQFFXPQJLZFABJ-UHFFFAOYSA-N

Description

Application

AH6809 has been used:

• as a prostaglandin E2 receptor 1 & 2 (EP1/2) antagonist to analyze its effects on cyclooxygenase-2 /prostaglandin E2 (COX-2/PGE2) signaling in the angiogenic feedback of endothelial cells to hypoxia
• as an EP2 antagonist to study its effects on tumor angiogenesis in human prostate cancer cell lines
• as an EP2 antagonist to analyze its effects on overexpression of amyloid precursor protein (APP)

Actions biochimiques/physiologiques

AH6809 plays a role in antagonizing the proliferation of non-small cell lung cancer cell lines.

DP/EP prostanoid receptor antagonist; has the highest affinity for DP receptors, but also acts as a weak antagonist at murine EP₁ and EP₂ prostanoid receptors.

Caractéristiques et avantages

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)