A1737

A922500

• Formule empirique (notation de Hill) : C₂₆H₂₄N₂O₄
• CAS Number: 959122-11-3
• Poids moléculaire : 428.48
• Numéro MDL: MFCD12828780
• Code UNSPSC : 12352204
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 100
• Essai: >95% (HPLC)
• Forme: powder
• Poids mol.: M_w 428.5
• Solubilité: DMSO: 10 mg/mL, clear, colorless to greenish-yellow
• Température de stockage: −20°C
• Chaîne SMILES: N(c2ccc(cc2)c3ccc(cc3)C(=O)[C@H]4[C@@H](CCC4)C(=O)O)C(=O)Nc1ccccc1
• InChI: 1S/C26H24N2O4/c29-24(22-7-4-8-23(22)25(30)31)19-11-9-17(10-12-19)18-13-15-21(16-14-18)28-26(32)27-20-5-2-1-3-6-20/h1-3,5-6,9-16,22-23H,4,7-8H2,(H,30,31)(H2,27,28,32)/t22-,23-/m1/s1
• Clé InChI: BOZRFEQDOFSZBV-DHIUTWEWSA-N

Description

Application

A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages.

Actions biochimiques/physiologiques

Diacylglycerol acyltransferase (DGAT-1) inhibitor; IC₅₀ 7 to 24 nM

The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease.

Forme physique

A922500 is supplied as a crystalline solid.

Notes préparatoires

A stock solution may be made by dissolving the A922500 in the solvent of choice. A922500 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable