SML1075

Atglistatin

≥98% (HPLC), powder, adipose triglyceride lipase inhibitor

• Synonyme(s) : 3-(4′-(Dimethylamino)-[1,1′-biphenyl]-3-yl)-1,1-dimethylurea
• Formule empirique (notation de Hill) : C₁₇H₂₁N₃O
• CAS Number: 1469924-27-3
• Poids moléculaire : 283.37
• Numéro MDL: MFCD28009494
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825457
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Atglistatin, ≥98% (HPLC)
• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: CN(C)C(NC1=CC=CC(C2=CC=C(N(C)C)C=C2)=C1)=O
• InChI: 1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21)
• Clé InChI: AWOPBSAJHCUSAS-UHFFFAOYSA-N

Description

Application

Atglistatin has been used as a selective inhibitor of adipose triglyceride lipase (ATGL).

Actions biochimiques/physiologiques

Atglistatin is a selective inhibitor of adipose triglyceride lipase (ATGL).

Atglistatin is the first selective inhibitor of adipose triglyceride lipase (ATGL), the rate limiting enzyme involved in the mobilization of fatty acids from cellular triglyceride stores. Atglistatin has an IC₅₀ of 0.7 μM in E.coli and no activity against monoglycerol lipase (MGL), hormone-sensitive lipase (HSL), or pancreatic lipase and lipoprotein lipase PNPLA6 and PNPLA7. ATGL generates diacylglycerol from cellular triglyceride stores, which is then degraded by hormone-sensitive lipase (HSL) and monoglyceride lipase into glycerol and fatty acids, promoting the synthesis of lipotoxic metabolites that have been associated with the development of insulin resistance. Atglistatin inhibition of ATGL has been shown to reduce fatty acid mobilization in vitro and in vivo.

Autres remarques

Produced under the license of University of Graz/Graz University of Technolog

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable