A4847

Alsterpaullone

≥98% (HPLC), powder

• Synonyme(s) : 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one
• Formule empirique (notation de Hill) : C₁₆H₁₁N₃O₃
• CAS Number: 237430-03-4
• Poids moléculaire : 293.28
• Numéro MDL: MFCD02683579
• Code UNSPSC : 12352200
• ID de substance PubChem : 24890918
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: yellow to brown
• Solubilité: DMSO: ≥10 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: [O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
• InChI: 1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
• Clé InChI: OLUKILHGKRVDCT-UHFFFAOYSA-N
• Informations sur le gène: rat ... Gsk3b(84027)

Description

Application

Alsterpaullone has been used to stabilize β-catenin.

Alsterpaullone inhibits GSK-3β, CDK5/p25, and CDK1/cyclin B. Alsterpaullone has also been studied as an antimanic therapeutic for the acute manic phase of bipolar disorder.

Actions biochimiques/physiologiques

Alsterpaullone (ALP) is a cyclin-dependent kinase (CDK) inhibitor. It is considered as a therapeutic agent for group 3 medulloblastomas. Alsterpaullone modulates the progression of cell cycle. It can arrest cell cycle and stimulate the apoptosis of cancer cells by activating caspase-9 through perturbation of mitochondrial membrane potential.

Potent and selective inhibitor of GSK-3β and CDK5/p25; potent inhibitor of CDK1/cyclin B (IC₅₀ = 0.035 μM).

Caractéristiques et avantages

This compound is featured on the CDKs and GSK-3 pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves