A5376

Acetylsalicylic acid

≥99.0%

• Synonyme(s) : 2-Acetoxybenzoic acid, O-Acetylsalicylic acid, ASA, Aspirin
• Formule linéaire : 2-(CH₃CO₂)C₆H₄CO₂H
• CAS Number: 50-78-2
• Poids moléculaire : 180.16
• Beilstein: 779271
• Numéro CE : 200-064-1
• Numéro MDL: MFCD00002430
• Code UNSPSC : 12352106
• ID de substance PubChem : 24278218
• Nomenclature NACRES : NA.21

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 200
• Essai: ≥99.0%
• Forme: powder
• Couleur: white
• pKa (25 °C): 3.5
• Pf: 134-136 °C (lit.)
• Solubilité: H₂O: 10 mg/mL at 37 °C(lit.); H₂O: 3 mg/mL at 25 °C(lit.); ethanol: 50 mg/mL; aqueous base: decomposes
• ε (coefficient d'extinction): 190 at 298 nm in aqueous base at 1 mM; 409 at 231 nm in aqueous base at 1 mM; 466 at 230 nm in aqueous acid at 1 mM; 68 at 278 nm in aqueous acid at 1 mM
• Chaîne SMILES: CC(=O)Oc1ccccc1C(O)=O
• InChI: 1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
• Clé InChI: BSYNRYMUTXBXSQ-UHFFFAOYSA-N
• Informations sur le gène: human ... ITGA2B(3674), ITGB3(3690), PTGS1(5742), PTGS2(5743)

Description

Description générale

Acetylsalicylic acid is an organic compound commonly referred to as aspirin. It works by blocking the production of compounds in the body that cause pain, swelling, and fever. Acetylsalicylic acid also serves a vital function in preventing blood clots from forming in the arteries. In research, acetylsalicylic acid is studied for its role in oxidative stress, and in cancer research as a biomarker.

Actions biochimiques/physiologiques

Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 482.0 °F
• Point d'éclair (°C): 250 °C
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves