A7410

Amiloride hydrochloride hydrate

≥98% (HPLC), powder, T-type calcium channel blocker

• Synonyme(s) : N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate
• Formule empirique (notation de Hill) : C₆H₈ClN₇O · HCl · xH₂O
• CAS Number: 2016-88-8
• Poids moléculaire : 266.09 (anhydrous basis)
• Numéro MDL: MFCD03703482
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277817
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Amiloride hydrochloride hydrate, ≥98% (HPLC), powder
• Niveau de qualité: 200
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: yellow
• Pf: 285-288 °C (dec.)
• Solubilité: H₂O: 50 mg/mL, clear, yellow-green
• Auteur: Perrigo
• Température de stockage: room temp
• Chaîne SMILES: O.Cl.NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
• InChI: 1S/C6H8ClN7O.ClH.H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;/h(H4,8,9,13)(H4,10,11,14,15);1H;1H2
• Clé InChI: WDZJJRLYFQNCQL-UHFFFAOYSA-N
• Informations sur le gène: human ... ABP1(26), ACCN1(40), ACCN2(41), PLAU(5328), SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), TNF(7124) ; mouse ... Abp1(76507), Accn1(11418), Accn2(11419), Plau(18792), Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278), Slc9a1(20544) ; rat ... Abp1(65029), Accn1(25364), Accn2(79123), Plau(25619), Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782)

Description

Application

Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA). Amiloride has been used in a study to develop an alternative treatment for constipation.

Actions biochimiques/physiologiques

Selective T-type Ca²⁺ and epithelial sodium channel blocker

Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA).

Caractéristiques et avantages

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Perrigo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Attention

Protect from light.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges