T4143

Triamterene

≥99%

• Synonyme(s) : 2,4,7-Triamino-6-phenylpteridine, 6-Phenyl-2,4,7-pteridinetriamine
• Formule empirique (notation de Hill) : C₁₂H₁₁N₇
• CAS Number: 396-01-0
• Poids moléculaire : 253.26
• Numéro CE : 206-904-3
• Numéro MDL: MFCD00006708
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277877
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥99%
• Solubilité: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 1.2 mg/mL; DMSO: soluble 5.4 mg/mL; H₂O: insoluble
• Auteur: Wellspring
• Chaîne SMILES: Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1
• InChI: 1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
• Clé InChI: FNYLWPVRPXGIIP-UHFFFAOYSA-N
• Informations sur le gène: human ... SCNN1A(6337), SCNN1B(6338), SCNN1G(6340)

Description

Application

Triamterene has been used to study its effects on urokinase receptor (uPAR) induction in podocytes under in vitro conditions². Triamterene has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay³.

Actions biochimiques/physiologiques

Weak diuretic with potassium sparing properties; blocks Na⁺ reuptake in the kidneys.

Caractéristiques et avantages

This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Notes préparatoires

200 mg of triamterene is soluble in 4 ml of warm formic acid and yields a clear, yellow-green solution. Triamterene is also soluble in DMSO (5.4 mg/ml), and in 45% (w/v) aqueous 2-hydroxypropyl-β-cyclodextrin (1.2 mg/ml). However, it is insoluble in water.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315,H319,H335
• Conseils de prudence: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves