A8016

Adenosine 5′-[β-thio]diphosphate trilithium salt

≥80% (HPLC)

• Synonyme(s) : ADP-β-S, Adenosine-5′-0-(2-thiodiphosphate) trilithium salt, Ado-5′-PP[S]
• Formule empirique (notation de Hill) : C₁₀H₁₂Li₃N₅O₉P₂S
• CAS Number: 73536-95-5
• Poids moléculaire : 461.07
• Numéro MDL: MFCD00077314
• Code UNSPSC : 41106305
• eCl@ss : 32160414
• ID de substance PubChem : 24891307
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: ≥80% (HPLC)
• Forme: powder
• Température de stockage: −20°C
• Chaîne SMILES: [Li+].[Li+].[Li+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O
• InChI: 1S/C10H15N5O9P2S.3Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(23-10)1-22-25(18,19)24-26(20,21)27;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H2,20,21,27);;;/q;3*+1/p-3/t4-,6-,7-,10-;;;/m1.../s1
• Clé InChI: CPKFUAYUUSSFFZ-MSQVLRTGSA-K

Description

Application

Adenosine 5′-[β-thio]diphosphate is a substrate and inhibitor for AMP dependent enzyme systems. Adenosine 5′-[β-thio]diphosphate has been used to explore the myenteric control mechanisms of human esophageal motility and the effect of nitrergic and nonnitrergic neurotransmitters.

Adenosine 5′-[β-thio]diphosphate trilithium salt has been used to induce neuropathic pain in rats to study the effect of dorsal horn cannabinoid CB2 receptor activation on the expression of P2Y12 and P2Y13 (purinoceptors) receptors.

Actions biochimiques/physiologiques

P2Y receptor agonist.

Caractéristiques et avantages

This compound is featured on the P2 Receptors: P2Y G-Protein Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Autres remarques

Non-hydrolyzable ADP analog

Substrats

Substrate and inhibitor for AMP dependent enzyme systems.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H371
• Conseils de prudence: P260 - P264 - P301 + P312 - P308 + P311 - P405 - P501
• Classification des risques: Acute Tox. 4 Oral - STOT SE 2
• Organes cibles: Eyes,Central nervous system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves