A8404

Amitriptyline hydrochloride

≥98% (TLC), powder

• Formule empirique (notation de Hill) : C₂₀H₂₃N · HCl
• CAS Number: 549-18-8
• Poids moléculaire : 313.86
• Numéro CE : 208-964-6
• Numéro MDL: MFCD00012537
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278073
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: ≥98% (TLC)
• Forme: powder
• Couleur: white to off-white
• Solubilité: H₂O: soluble; ethanol: soluble
• Auteur: Bristol-Myers Squibb
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
• InChI: 1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
• Clé InChI: KFYRPLNVJVHZGT-UHFFFAOYSA-N
• Informations sur le gène: human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), SLC6A2(6530), SLC6A4(6532)

Description

Application

Amitriptyline hydrochloride has been used:

• as an antidepressant to study its effects on social behavior and memory in transgenic for acid sphingomyelinase (t-ASM) mice
• as a tricyclic antidepressant to analyze its effects on glucocorticoid receptor function in whole human blood
• as an anti-depressant to study its effects on scratching and locomotion behavior in chloroquine-induced mouse

Actions biochimiques/physiologiques

Amitriptyline hydrochloride shows therapeutic effects against anxiety, maniac depression, and involutional melancholia. It possesses antihistaminic, anticholinergic, and antiserotonimic properties. Amitriptyline hydrochloride acts as an amphiphilic agent and exhibits neuroleptic activity.

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with K_is of 100 nM and 14.7 nM, respectively; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Tricyclic antidepressant; norepinephrine and serotonin transporter inhibitor; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Caractéristiques et avantages

Shelf-life of the powder is at least three years.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H301,H319,H361d,H410
• Conseils de prudence: P201 - P273 - P301 + P310 + P330 - P305 + P351 + P338
• Classification des risques: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges