A9106

ADP-ribosylcyclase

1000-3000 units/mg protein

• Synonyme(s) : Adenosine diphosphoribose cyclase from Aplysia californica
• CAS Number: 135622-82-1
• Numéro MDL: MFCD00212894
• Code UNSPSC : 12352204
• Nomenclature NACRES : NA.54

Propriétés

• Source biologique: (Aplysia californica)
• Niveau de qualité: 200
• Essai: ≥80 μ protein/vial (BCA)
• Forme: lyophilized powder
• Activité spécifique: 1000-3000 units/mg protein
• Composition: Protein, ≤10%
• Conditionnement: vial of ≥80 μg protein
• Conditions de stockage: dry at room temperature
• Concentration: ≤10% (BCA method)
• Adéquation: suitable for enzyme test
• Application(s): genomic analysis
• Température de stockage: −20°C

Description

Application

ADP-ribosylcyclase is a Ca²⁺ signaling second messenger. It may be used to study calcium signaling and has been used to research morphine antinociception and tolerance .

Actions biochimiques/physiologiques

ADP-ribosylcyclase is an intracellular calcium regulator that cyclizes NAD into cADPR. It is thought that the majority of ADP-ribosylcyclase activity in the brain is linked to CD38. Nicotinamide is a known inhibitor of CD38 ADP-ribosylcyclase activity .

Définition de l'unité

One unit will produce 1 μmole of cyclic ADP ribose from β-NAD⁺ in 5 minutes at pH 7.0 and 25°C.

Forme physique

Lyophilized powder containing trehalose, potassium phosphate and dithiothreitol

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H334
• Conseils de prudence: P261 - P284 - P501
• Classification des risques: Resp. Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)