C1335

S-(−)-Carbidopa

≥98% (TLC), powder

• Synonyme(s) : (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid, S-(−)-α-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid
• Formule empirique (notation de Hill) : C₁₀H₁₄N₂O₄
• CAS Number: 28860-95-9
• Poids moléculaire : 226.23
• Numéro CE : 249-271-9
• Numéro MDL: MFCD00069231
• Code UNSPSC : 12352202
• ID de substance PubChem : 24892402
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: ≥98% (TLC)
• Forme: powder
• Solubilité: methanol and 1 drop HCl: 4.90-5.10 mg/mL, clear, colorless to faintly yellow
• Température de stockage: −20°C
• Chaîne SMILES: CC(Cc1ccc(O)c(O)c1)(NN)C(O)=O
• InChI: 1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1
• Clé InChI: TZFNLOMSOLWIDK-JTQLQIEISA-N
• Informations sur le gène: human ... DDC(1644)

Description

Description générale

Carbidopa is used for treating restless legs (RL) syndrome and periodic leg movements in sleep (PLMS). Carbidopa along with levodopa is used to treat Parkinson′s disease.

Actions biochimiques/physiologiques

Peripheral inhibitor of L-aromatic amino acid decarboxylase.

Peripheral inhibitor of L-aromatic amino acid decarboxylase. When co-administered with L-DOPA, it prevents extra-CNS conversion to dopamine, thereby increasing CNS concentrations of effective compounds. Selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells by increasing H₂O₂ in these cell lines, which are sensitive to reactive oxygen species.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)