C2755

Cortisone

≥95%

• Synonyme(s) : 17α,21-Dihydroxy-4-pregnene-3,11,20-trione, 17α-Hydroxy-11-dehydrocorticosterone, 4-Pregnene-17α,21-diol-3,11,20-trione, Kendall’s Compound E, Reichstein’s Substance Fa
• Formule empirique (notation de Hill) : C₂₁H₂₈O₅
• CAS Number: 53-06-5
• Poids moléculaire : 360.44
• Beilstein: 1356062
• Numéro CE : 200-162-4
• Numéro MDL: MFCD00003610
• Code UNSPSC : 51111800
• ID de substance PubChem : 24278304
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 200
• Stérilité: non-sterile
• Essai: ≥95%
• Forme: powder
• Technique(s): inhibition assay: suitable
• Pf: 223-228 °C (dec.) (lit.)
• Solubilité: chloroform: methanol (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• Conditions d'expédition: ambient
• Température de stockage: room temp
• Chaîne SMILES: C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)CC(=O)[C@H]23
• InChI: 1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
• Clé InChI: MFYSYFVPBJMHGN-ZPOLXVRWSA-N
• Informations sur le gène: human ... SERPINA6(866)

Description

Application

Cortisone has been used:

• to validate a 1β-HSD1 (11β-hydroxysteroid dehydrogenase type 1) inhibitor
• to study the sensitivity of erythropoietic and granulopoietic progenitor cells to cortisone
• in the determination of rates of cortisol oxidation by 11βHSD

Actions biochimiques/physiologiques

Cortisone (11 dehydro 17 hydroxycortico-sterone) is an anti-inflammatory glucocorticoid that delays wound healing after surgeries. It postpones the healing process by affecting the appearance of inflammatory cells, ground substance, fibroblasts, collagen, regenerating capillaries, and epithelial migration. Glucocorticoids have anti-inflammatory, anti-allergic and immunosuppressive properties and are extensively used in treatment and therapy.

Cortisone is a glucocorticoid; a corticosterone analog that has approximately twice the anti-inflammatory potency as corticosterone but much lower Na²⁺ retention potency.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Warning
• Mentions de danger: H361d
• Conseils de prudence: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Repr. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)