C4369

Calcipotriol hydrate

≥98% (HPLC), powder, Vitamin D3 analog

• Synonyme(s) : (5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1alpha,3beta,24-triol, Calcipotriene
• Formule empirique (notation de Hill) : C₂₇H₄₀O₃ · xH₂O
• CAS Number: 112965-21-6
• Poids moléculaire : 412.60 (anhydrous basis)
• Numéro MDL: MFCD10567086
• Code UNSPSC : 12352200
• ID de substance PubChem : 329775060
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Calcipotriol hydrate, ≥98% (HPLC)
• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Solubilité: DMSO: 15 mg/mL, clear
• Température de stockage: room temp
• Chaîne SMILES: O.C[C@H](\C=C\[C@@H](O)C1CC1)C2CCC3\C(CCC[C@]23C)=C\C=C4\C[C@@H](O)C[C@H](O)C4=C
• InChI: 1S/C27H40O3.H2O/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2;/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3;1H2/b13-6+,19-7+,21-10-;/t17-,22-,23-,24+,25-,26+,27-;/m1./s1
• Clé InChI: XBKHACNRWFKJNC-MANNPBRJSA-N

Description

Actions biochimiques/physiologiques

Calcipotriol is a synthetic derivative of calcitriol, or Vitamin D.

Calcipotriol, a synthetic derivative of calcitriol or Vitamin D, is used in the treatment of psoriasis and marketed under the trade name Dovonex. It has comparable affinity with calcitriol (Vit. D) for the Vitamin D receptor (VDR), while being less than 1% as active as the calcitriol in regulating calcium metabolism. VDR belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kindney, and T cells of the immune system. Binding of calcipotriol to the VDR modulates the T cells gene transcription of cell differentiation and proliferation-related genes.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H300 + H310,H317,H319,H361fd,H372
• Conseils de prudence: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P310 - P305 + P351 + P338
• Classification des risques: Acute Tox. 1 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Repr. 2 - Skin Sens. 1B - STOT RE 1
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves