C8180

Cholera Toxin A Subunit from Vibrio cholerae

lyophilized powder

• Numéro MDL: MFCD00130777
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Forme: lyophilized powder
• Niveau de qualité: 200
• Composition: Protein, ~5% Lowry
• Disponibilité: not available in Japan
• Impuretés: ≤0.5% Cholera toxin B subunit (SDS-PAGE)
• Température de stockage: 2-8°C

Description

Description générale

Cholera Toxin (CT) is secreted by Vibrio cholerae. CT upregulates cell surface molecules, such as co-stimulatory molecules and chemokine receptors in antigen presenting cells(APCs), murine and human dendritic cells (DCs). It enhances the secretion of interleukin 1 (IL-1) from macrophages and stimulates their APC function. CT also functions as an immunomodulator.

Application

Cholera Toxin A Subunit from Vibrio cholerae has been used as a specific probe for trimeric G proteins in membrane motility assays.

Actions biochimiques/physiologiques

Catalyzes ADP-ribosylation of the α-subunit of G proteins, reducing GTPase activity and activating the α-subunit; also catalyzes ADP-ribosylation of cell membrane adenylyl cyclase

Forme physique

Lyophilized powder containing Tris buffer salts, sodium chloride, sodium azide and sodium EDTA

Reconstitution

When reconstituted with 1 mL of water, the solution will contain 0.05 M Tris buffer salts, pH 7.5, 0.2 M NaCl, 0.003 M NaN₃, and 0.001 M sodium EDTA. Store reconstituted solutions in the refrigerator.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H332,H412
• Conseils de prudence: P261 - P271 - P273 - P304 + P340 + P312 - P501
• Classification des risques: Acute Tox. 4 Inhalation - Aquatic Chronic 3
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable