C8895

Clofazimine

≥98% (TLC), powder, antimycobacterial rimonphenazine

• Synonyme(s) : N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine
• Formule empirique (notation de Hill) : C₂₇H₂₂Cl₂N₄
• CAS Number: 2030-63-9
• Poids moléculaire : 473.40
• Numéro CE : 217-980-2
• Numéro MDL: MFCD00056793
• Code UNSPSC : 12352200
• ID de substance PubChem : 24893114
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Clofazimine,
• Forme: powder
• Niveau de qualité: 200
• Spectre d'activité de l'antibiotique: mycobacteria
• Mode d’action: protein synthesis | interferes
• Auteur: Novartis
• Chaîne SMILES: CC(C)\N=C1/C=C2N(c3ccc(Cl)cc3)c4ccccc4N=C2C=C1Nc5ccc(Cl)cc5
• InChI: 1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+
• Clé InChI: WDQPAMHFFCXSNU-BGABXYSRSA-N

Description

Description générale

Clofazimine is a riminophenazine, which is used as an antileprosy drug. It is used to treat multidrug-resistant tuberculosis. Clofazimine prevents neutrophil motility and lymphocyte transformation. It has anti-inflammatory effect, which is used to treat discoid lupus erythematosus. Clofazimine has immunosuppressive property.

Application

Clofazimine has been used:

• for antimicrobial preparation
• to study its accumulation on macrophages to form crystal-like drug inclusions (CLDIs)
• to model drug-induced hepatic granulomatous inflammation
• to study the in vivo cargo storage capacity of macrophages

Caractéristiques et avantages

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Stockage et stabilité

This product is stored at room temperature.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves