I3377

Isoniazid

analytical standard, ≥99% (TLC)

• Synonyme(s) : 4-Pyridinecarboxylic acid hydrazide, INH, Isonicotinic acid hydrazide, Isonicotinic hydrazide
• Formule empirique (notation de Hill) : C₆H₇N₃O
• CAS Number: 54-85-3
• Poids moléculaire : 137.14
• Beilstein: 119374
• Numéro CE : 200-214-6
• Numéro MDL: MFCD00006426
• Code UNSPSC : 41116107
• ID de substance PubChem : 329815370
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: analytical standard
• Niveau de qualité: 100
• Essai: ≥99% (TLC)
• Technique(s): HPLC: suitable; gas chromatography (GC): suitable
• Pf: 171-173 °C (lit.)
• Fluorescence: λ_ex 360 nm; λ_em 450 nm (thiol adduct)
• Spectre d'activité de l'antibiotique: mycobacteria
• Application(s): forensics and toxicology; pharmaceutical (small molecule)
• Format: neat
• Chaîne SMILES: NNC(=O)c1ccncc1
• InChI: 1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
• Clé InChI: QRXWMOHMRWLFEY-UHFFFAOYSA-N

Description

Description générale

Chemical structure: pyridine

Isoniazid is a type of drug possessing antimycobacterial activity.It is used in the treatment of tuberculosis.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Actions biochimiques/physiologiques

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

Produits recommandés

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315
• Conseils de prudence: P264 - P280 - P301 + P312 - P302 + P352 - P332 + P313 - P362 + P364
• Classification des risques: Acute Tox. 4 Oral - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves