D2141

6-Diazo-5-oxo-L-norleucine

>95% (TLC), suitable for ligand binding assays

• Synonyme(s) : (S)-2-Amino-6-diazo-5-oxocaproic acid, DON
• Formule empirique (notation de Hill) : C₆H₉N₃O₃
• CAS Number: 157-03-9
• Poids moléculaire : 171.15
• Beilstein: 1725815
• Numéro MDL: MFCD00037218
• Code UNSPSC : 12352209
• ID de substance PubChem : 24893639
• Nomenclature NACRES : NA.26

Propriétés

• Product Name: 6-Diazo-5-oxo-L-norleucine, crystalline
• Essai: >95% (TLC)
• Niveau de qualité: 200
• Forme: crystalline
• Technique(s): ligand binding assay: suitable
• Couleur: light yellow
• Pf: 145 °C
• Spectre d'activité de l'antibiotique: neoplastics
• Mode d’action: enzyme | inhibits
• Température de stockage: −20°C
• Chaîne SMILES: N[C@@H](CCC(=O)C=[N+]=[N-])C(O)=O
• InChI: 1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/m0/s1
• Clé InChI: YCWQAMGASJSUIP-YFKPBYRVSA-N

Description

Description générale

Chemical structure: amino acid derivatives

Application

6-Diazo-5-oxo-L-norleucine (DON) has been used as an inhibitor of glutamine synthetase–glutamine(amide)-2-oxoglutarate aminotransferase.

Actions biochimiques/physiologiques

6-Diazo-5-oxo-L-norleucine (DON), a glutamine analogue, is used as an inhibitor to study the function, specificity and characteristics of cytidine triphosphate synthase 1(s) (CTPS1) and various glutaminase(s). DON is used to inhibit glutamine (GLN) flux between cells.

DON is associated with a number of reactions involving L-glutamine as a nitrogen source, such as nucleic acid and protein synthesis. It is known to possess anticancer activity against choriocarcinoma.

DON is used to study mechanisms of glutamine utilizing enzymes such as carbamoyl phosphate synthase and cytidine triphosphate synthase.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301 + H311 + H331
• Conseils de prudence: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges