D7692

Diethylumbelliferyl phosphate

≥98% (HPLC), oil

• Synonyme(s) : DEUP, UBP
• Formule empirique (notation de Hill) : C₁₄H₁₇O₆P
• CAS Number: 897-83-6
• Poids moléculaire : 312.25
• Code UNSPSC : 12352200
• ID de substance PubChem : 24894155
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: oil
• Couleur: colorless to yellow
• Solubilité: DMSO: >5 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: CCOP(=O)(OCC)Oc1ccc2C(C)=CC(=O)Oc2c1
• InChI: 1S/C14H17O6P/c1-4-17-21(16,18-5-2)20-11-6-7-12-10(3)8-14(15)19-13(12)9-11/h6-9H,4-5H2,1-3H3
• Clé InChI: GHGRYKAFUNNHBG-UHFFFAOYSA-N

Description

Application

Diethylumbelliferyl phosphate has been used as a lipase inhibitor to treat wild-type myeloblasts for in vitro neutrophil differentiation assays.

Actions biochimiques/physiologiques

Diethylumbelliferyl phosphate (DEUP), an organophosphate does not block protein kinase activity A in vitro.

Diethylumbelliferyl phosphate is a selective, potent cholesterol esterase inhibitor. It blocks steroidogenesis primarily by preventing cholesterol transport into the mitochondria of steroidogenic cells. Inhibitors of cholesterol esterase are anticipated to limit the absorption of dietary cholesterol. IC₅₀ = 11.6 μM.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H300
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 2 Oral
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges