D9250

2′-Deoxyguanosine 5′-diphosphate sodium salt

≥90% (HPLC)

• Synonyme(s) : dGDP
• Formule empirique (notation de Hill) : C₁₀H₁₅N₅O₁₀P₂ · xNa⁺
• CAS Number: 102783-74-4
• Poids moléculaire : 427.20 (free acid basis)
• Numéro MDL: MFCD00057075
• Code UNSPSC : 41106305
• ID de substance PubChem : 24894274
• Nomenclature NACRES : NA.51

Propriétés

• Niveau de qualité: 200
• Essai: ≥90% (HPLC)
• Forme: powder
• Solubilité: water: 50 mg/mL, clear, colorless
• Température de stockage: −20°C
• Chaîne SMILES: [Na].NC1=NC(=O)c2ncn(C3CC(O)C(COP(O)(=O)OP(O)(O)=O)O3)c2N1
• InChI: 1S/C10H15N5O10P2.Na.H/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20;;/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17);;
• Clé InChI: VLWIICGGBFZYEZ-UHFFFAOYSA-N

Description

Description générale

2′-Deoxyguanosine 5′-diphosphate (dGDP) is a nucleotide with guanine base, deoxyribose and two phosphate.

Application

2′-Deoxyguanosine 5′-diphosphate (dGDP) is used as a substrate of dGDP (nucleoside diphosphate) kinase (2.7.4.6) or pyruvate kinase to produce dGTP in support of DNA biosynthesis. dGDP is used as a substrate to study the kinetics of glycoprotein (gp) 1.7 expressed by bacteriophage T7.

2′-Deoxyguanosine 5′-diphosphate sodium salt has been used as a xanthosine 5′-monophosphate analog and xanthine phosphoribosyl transferase inhibitor in kinetic studies.

Actions biochimiques/physiologiques

2′-Deoxyguanosine 5′-diphosphate (dGDP) inhibits xanthine phosphoribosyl transferase (XPRT) and hypoxanthine-guanine phosphoribosyl transferase (HGPRT).

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves