E1406

Embelin

≥98% (HPLC), powder

• Synonyme(s) : 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione, Embelic acid, Emberine
• Formule empirique (notation de Hill) : C₁₇H₂₆O₄
• CAS Number: 550-24-3
• Poids moléculaire : 294.39
• Numéro CE : 208-979-8
• Numéro MDL: MFCD00016369
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724473
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: ≥98% (HPLC)
• Forme: powder
• Solubilité: DMSO: >10 mg/mL; H₂O: insoluble
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria; parasites
• Mode d’action: DNA synthesis | interferes
• Chaîne SMILES: CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
• InChI: 1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3
• Clé InChI: IRSFLDGTOHBADP-UHFFFAOYSA-N
• Informations sur le gène: human ... XIAP(331)

Description

Description générale

Embelin, a natural benzoquinone-derivative, was initially extracted from Embelia ribes plant. It is structurally similar to ubiquinone.

Application

Embelin has been used:

• to study its effects on the receptor activator of nuclear factor kappa-B ligand (RANKL)-induced nuclear factor of activated T cells (NFATc1) luciferase activity
• to study its role in the mechanisms mediating Parkinson′s disease (PD)
• in treating whole mouse embryos to determine its effects on the X-linked inhibitory apoptosis protein (XIAP) activity

Actions biochimiques/physiologiques

Embelin is an inhibitor of XIAP (X-linked inhibitor-of-apoptosis protein); in vivo antitumor and anti-inflammatory activity.

Embelin elicits anti-oxidant, mitochondrial uncoupling, and anti-fertility properties. It also has anti-diabetic, anti-convulsant, anxiolytic, and anti-microbial activities. Embelin acts as a potent neuroprotective agent and is also beneficial as an adjunct therapy for cerebral stroke.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Warning
• Mentions de danger: H361f
• Conseils de prudence: P201 - P308 + P313
• Classification des risques: Repr. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)