F9397

Flutamide

• Synonyme(s) : 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
• Formule empirique (notation de Hill) : C₁₁H₁₁F₃N₂O₃
• CAS Number: 13311-84-7
• Poids moléculaire : 276.21
• Numéro CE : 236-341-9
• Numéro MDL: MFCD00072009
• Code UNSPSC : 51111800
• ID de substance PubChem : 24278446
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Auteur: Schering Plough
• Chaîne SMILES: CC(C)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O
• InChI: 1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)
• Clé InChI: MKXKFYHWDHIYRV-UHFFFAOYSA-N
• Informations sur le gène: human ... AR(367) ; mouse ... Ar(11835) ; rat ... Ar(24208)

Description

Application

Flutamide has been used to effect of testosterone on Glial cell-derived neurotrophic factor (Gdnf) mRNA production in vitro. It has also been used to study the effects of flutamide on anogenital distance and nipple retention.

Actions biochimiques/physiologiques

Flutamide is a non-steroidal anti-androgen drug. It consists of a nitroaromatic structure. Flutamide is a potent competitor of testosterone and dihydrotestosterone receptors. It is a potent hepatotoxin.

Caractéristiques et avantages

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302,H351,H361,H373,H411
• Conseils de prudence: P202 - P260 - P264 - P273 - P301 + P312 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2 - STOT RE 2
• Organes cibles: Liver
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges