G1887

Gly-His-Lys acetate salt

≥97% (TLC)

• Synonyme(s) : Liver cell growth factor
• Formule linéaire : C₁₄H₂₄N₆O₄C₂H₄O₂
• CAS Number: 72957-37-0
• Poids moléculaire : 400.43
• Numéro MDL: MFCD00012699
• Code UNSPSC : 51111800
• ID de substance PubChem : 24894913
• Nomenclature NACRES : NA.32

Propriétés

• Niveau de qualité: 200
• Essai: ≥97% (TLC)
• Composition: Peptide content, ~70%
• Température de stockage: −20°C
• Chaîne SMILES: CC(O)=O.NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN)C(O)=O
• InChI: 1S/C14H24N6O4.C2H4O2/c15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9;1-2(3)4/h7-8,10-11H,1-6,15-16H2,(H,17,18)(H,19,21)(H,20,22)(H,23,24);1H3,(H,3,4)/t10-,11-;/m0./s1
• Clé InChI: MGNUTAFMLGJBGV-ACMTZBLWSA-N

Description

Amino Acid Sequence

Gly-His-Lys

Description générale

Gly-His-Lys is a tripeptide present at ∼200ng/ml in association with α-globulin and albumin, in human blood plasma.

Application

Gly-His-Lys (GHK) has been used for the preparation of post-operative intra-articular injection of GHK-Cu (copper).

Gly-His-Lys acetate salt has been used:

• individually or as a complex with copper to test its effect on cytokines production in the human normal fibroblasts cell lines
• as a model peptide in N,N-dimethyl-N-methacryloxyethyl-N-(3-sulfopropyl)ammonium betaine based capillary electrophoresis separation studies
• as a component of Coon′s modified Ham′s F-12 medium for culturing Fischer rat thyroid follicular cell line, FRTL-5

Actions biochimiques/physiologiques

Gly-His-Lys (GHK) acetate salt displays affinity towards copper(II) ions. This property enables GHK to modulate the copper intake into cells. GHK is also involved in quenching toxic by-products generated by lipid peroxidation.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable