G4541

Gly-Gly-His

≥98% (TLC)

• Synonyme(s) : Copper-binding peptide
• Formule empirique (notation de Hill) : C₁₀H₁₅N₅O₄
• CAS Number: 7451-76-5
• Poids moléculaire : 269.26
• Numéro MDL: MFCD03452928
• Code UNSPSC : 12352209
• Nomenclature NACRES : NA.26

Propriétés

• Product Name: Gly-Gly-His,
• Essai: ≥98% (TLC)
• Niveau de qualité: 200
• Forme: solid
• Couleur: white
• Température de stockage: −20°C
• InChI: 1S/C10H15N5O4/c11-2-8(16)13-4-9(17)15-7(10(18)19)1-6-3-12-5-14-6/h3,5,7H,1-2,4,11H2,(H,12,14)(H,13,16)(H,15,17)(H,18,19)
• Clé InChI: PDAWDNVHMUKWJR-UHFFFAOYSA-N

Description

Amino Acid Sequence

Gly-Gly-His

Description générale

Gly-Gly-His (GGH) tripeptide with carboxyl-terminal histidine residue is hydrophilic.

Application

Gly-Gly-His has been used:

• as a peptide test probe in the hydrophilic interaction liquid chromatography (HILIC) studies
• in the electrochemical modification of back-side contact transducers (BSC) electrodes in copper (Cu²⁺) sensing studies
• for the fabrication carbon nanotube electrode for detection of Cu²⁺ ions

Actions biochimiques/physiologiques

Gly-Gly-His (GGH) tripeptide displays the affinity of copper (Cu²⁺) complexation. These complexes display good skin tolerance and may be useful in wound healing. GGH copper complexes are proposed to reduce tumor necrosis factor α (TNF-α)-based interleukin 6 (IL-6) secretion by in vivo studies with fibroblasts. GGH is used in comparative studies with other imidazole-containing peptides such as carnosine. An area of active application research involves the GGH binding of copper ions.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)