G6264

Guanosine

BioReagent, suitable for cell culture

• Synonyme(s) : 9-(β-D-Ribofuranosyl)guanine, Guanine-9-β-D-ribofuranoside
• Formule empirique (notation de Hill) : C₁₀H₁₃N₅O₅
• CAS Number: 118-00-3
• Poids moléculaire : 283.24
• Beilstein: 625911
• Numéro CE : 204-227-8
• Numéro MDL: MFCD00010182
• Code UNSPSC : 12352205
• ID de substance PubChem : 24895251
• Nomenclature NACRES : NA.75

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 200
• Gamme de produits: BioReagent
• Essai: ≥98%
• Forme: powder
• Technique(s): cell culture | mammalian: suitable
• Pf: 250 °C (dec.) (lit.)
• Solubilité: 0.05 M acetic acid: 1 mg/mL, clear, colorless
• Conditions d'expédition: ambient
• Température de stockage: room temp
• Chaîne SMILES: [H]O[H].NC1=Nc2c(ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1
• InChI: 1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
• Clé InChI: NYHBQMYGNKIUIF-UUOKFMHZSA-N

Description

Application

Guanosine has been used:

• as a ribonucleoside component of the basal medium to study its effects on Bacillus mojavensis′s anaerobic growth
• as a component of the Dulbecco′s modified Eagle medium (DMEM) to culture mouse-derived embryonic stem cells
• as a component of the nucleoside solution to culture chicken embryonic stem cells

Actions biochimiques/physiologiques

Guanosine is a purine nucleoside that exhibits important functions in cell metabolism. It has also shown neuroprotective and neurotrophic effects in glial cells, hippocampal neurons, and pheochromocytoma cells by inducing proliferation and differentiation and also exerting anti-apoptotic effects. Guanosine acts as a therapeutic agent against several neuropathologies. It exerts its effects against sepsis-induced cognitive impairment, hepatic encephalopathy, lipopolysaccharide (LPS)-induced inflammation, ischemic injury, and azide-induced oxidative damage. Guanosine is suitable for use in cell culture applications as a precursor of guanosine monophosphate (GMP), guanosine diphosphate (GDP), guanosine triphosphate (GTP), and cyclic GMP (cGMP).

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges