G6295

GW3965 hydrochloride

≥98% (HPLC), powder, liver X receptors agonist

• Synonyme(s) : 3-[3-[N-(2-Chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
• Formule empirique (notation de Hill) : C₃₃H₃₁F₃ClNO₃ · HCl
• CAS Number: 405911-17-3
• Poids moléculaire : 618.51
• Numéro MDL: MFCD08276920
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724494
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: GW3965 hydrochloride, ≥98% (HPLC), powder
• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white
• Solubilité: DMSO: ≥20 mg/mL
• Auteur: GlaxoSmithKline
• Chaîne SMILES: Cl[H].OC(=O)Cc1cccc(OCCCN(CC(c2ccccc2)c3ccccc3)Cc4cccc(c4Cl)C(F)(F)F)c1
• InChI: 1S/C33H31ClF3NO3.ClH/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26;/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40);1H
• Clé InChI: NMPUWJFHNOUNQU-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC₅₀ = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC₅₀ = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC₅₀ = 60 nM and 85 nM in the cell-free and cell-based assays, respectively.

Caractéristiques et avantages

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS05,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H318,H413
• Conseils de prudence: P264 - P273 - P280 - P301 + P312 - P305 + P351 + P338 - P501
• Classification des risques: Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Dam. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves