G7048

Proguanil hydrochloride

≥95% (HPLC)

• Synonyme(s) : Chlorguanide, N¹-(4-Chlorophenyl)-N⁵-isopropylbiguanide
• Formule empirique (notation de Hill) : C₁₁H₁₆ClN₅·HCl
• CAS Number: 637-32-1
• Poids moléculaire : 290.19
• Numéro CE : 211-283-7
• Numéro MDL: MFCD01732193
• Code UNSPSC : 51101906
• ID de substance PubChem : 329799959
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: solid
• Conditions de stockage: desiccated
• Solubilité: acetonitrile: water: ~1 mg/mL (60/40)
• Auteur: AstraZeneca
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1
• InChI: 1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H
• Clé InChI: SARMGXPVOFNNNG-UHFFFAOYSA-N

Description

Application

Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.

Actions biochimiques/physiologiques

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

Caractéristiques et avantages

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable