I2411

Isocitrate Dehydrogenase 1 (NADP+) human

recombinant, expressed in Sf9 cells, ≥90% (SDS-PAGE)

• Synonyme(s) : IDH1, Isocitrate Dehydrogenase Cytoplasmic
• CAS Number: 9028-48-2
• Numéro CE : 1.1.1.42 (BRENDA, IUBMB)
• Code UNSPSC : 12352204
• Nomenclature NACRES : NA.54

Propriétés

• Produit recombinant: expressed in Sf9 cells
• Niveau de qualité: 200
• Essai: ≥90% (SDS-PAGE)
• Forme: buffered aqueous glycerol solution
• Poids mol.: 47.6 kDa
• Concentration: ≥0.30 mg/mL protein (Bradford)
• Numéro d'accès NCBI: NM_005896
• Maladie(s) pertinente(s): cancer (lung)
• Conditions d'expédition: dry ice
• Température de stockage: −70°C

Description

Description générale

Human Isocitrate Dehydrogenase (IDH1), also known as oxalosuccinate decarboxylase, full length [amino acids 1-414 (end)] with C-terminal FLAG-tag, expressed in Sf9 cells via a baculovirus expression system.

Application

Human Isocitrate Dehydrogenase (IDH1) is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. It may be useful as a biomarker for diagnosis and prognosis prediction of non-small cell lung cancer .

Actions biochimiques/physiologiques

Human Isocitrate Dehydrogenase (IDH1), also known as oxalosuccinate decarboxylase, is a full length amino acid with a C-terminal FLAG-tag and is expressed in Sf9 cells via a baculovirus expression system. IDH1 expression has been correlated with poor survival of non-small cell lung cancer. IDH1 promotes tumor growth .

Forme physique

Solution in 45 mM Tris-HCl, 124 mM NaCl, 2.4 mM KCl, 90 μg/ml FLAG peptide, 3 mM DTT, and 10% glycerol at pH 8.0.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable