I7908

IL-2 human

≥98% (SDS-PAGE and HPLC), recombinant, expressed in Pichia pastoris, lyophiilized powder, suitable for cell culture

• Synonyme(s) : IL-2, Interleukin-2, T-cell growth factor
• Numéro MDL: MFCD00165721
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.75

Propriétés

• Product Name: Interleukin-2 human, recombinant, expressed in Pichia pastoris, suitable for cell culture
• Source biologique: human
• Niveau de qualité: 200
• Produit recombinant: expressed in Pichia pastoris
• Essai: ≥98% (SDS-PAGE and HPLC)
• Forme: lyophilized powder
• Poids mol.: predicted mol wt ~15 kDa
• Conditionnement: pkg of 10KU
• Technique(s): cell culture | mammalian: suitable
• Impuretés: endotoxin, tested
• Numéro d'accès UniProt: P60568
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Informations sur le gène: human ... IL2(3558)

Description

Application

Interleukin-2 human has been used to assess changes in tumor necrosis factor receptor 1 (TNFR1). It has also been used in TNFR2 expression on Tregs.

Actions biochimiques/physiologiques

Interleukin 2 (IL2) is a pro-inflammatory cytokine. It consists of three subunits, in which the β subunit is important for receptor mediated signaling. IL2 enhances the development of T regulatory cells and plays a crucial role in antitumor immunity.

Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Forme physique

Lyophilized from a 0.2 μm filtered solution in 50 mM sodium phosphate buffer, pH 7.0, containing 0.1% human serum albumin per 0.1 mL of cytokine.

Remarque sur l'analyse

The biological activity is tested in a cell proliferation assay using an IL-2 dependent murine cytotoxic T cell line, CTLL-2.

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)