K1639

K-252a

from Nonomuraea longicatena, ≥98% (HPLC)

• Formule empirique (notation de Hill) : C₂₇H₂₁N₃O₅
• CAS Number: 99533-80-9
• Poids moléculaire : 467.47
• Numéro MDL: MFCD00161522
• Code UNSPSC : 12352200
• ID de substance PubChem : 24896210
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: Nonomuraea longicatena
• Niveau de qualité: 200
• Essai: ≥98% (HPLC)
• Forme: solid
• Solubilité: DMF: 1 mg/mL; DMSO: 1 mg/mL
• Spectre d'activité de l'antibiotique: viruses
• Mode d’action: enzyme | inhibits
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: [H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
• InChI: 1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
• Clé InChI: KOZFSFOOLUUIGY-SOLYNIJKSA-N
• Informations sur le gène: human ... NTRK1(4914) ; rat ... Prkca(24680)

Description

Application

K-252a has been used:

• as a tropomyosin receptor kinase (Trk) inhibitor to study the role of TrkA signaling in rats
• as a Trk inhibitor for inducing in vitro injury in retinal Müller glial cells to study the effects of cord blood serum (CBS)
• as a general protein kinase inhibitor to study its effect on in vitro human somatic testicular cell reassembly

Actions biochimiques/physiologiques

K-252a is a selective inhibitor of tyrosine protein kinase. It targets a wide range of protein kinases with IC₅₀ values between 3 and 25nM and the neurotrophin receptor-tropomyosin receptor kinase.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)