K2015

K-252a

Ready Made Solution, from Nonomuraea longicatena, >98%

• Synonyme(s) : SF 2370
• Formule empirique (notation de Hill) : C₂₇H₂₁N₃O₅
• CAS Number: 99533-80-9
• Poids moléculaire : 467.47
• Numéro CE : 200-664-3
• Numéro MDL: MFCD00161522
• Code UNSPSC : 12352200
• ID de substance PubChem : 329817131
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: Nonomuraea longicatena
• Niveau de qualité: 200
• Essai: >98%
• Forme: solution
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: [H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
• InChI: 1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
• Clé InChI: KOZFSFOOLUUIGY-SOLYNIJKSA-N
• Informations sur le gène: human ... NTRK1(4914) ; rat ... Prkca(24680)

Description

Actions biochimiques/physiologiques

K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor. At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of primary neuronal cultures. K-252a induces cell cycle arrest and apoptosis by inhibiting both Cdc2 and Cdc25c. K-252a improves psoriasis in a SCID mouse-human skin model and also suppresses referred mechanical hypersensitivity and neuropeptide up-regulation associated with acute pancreatitis.

Caractéristiques et avantages

This compound is featured on the Met and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Forme physique

Supplied as a 0.2 μm-filtered 1 mM solution in dimethyl sulfoxide (DMSO).

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 188.6 °F - closed cup
• Point d'éclair (°C): 87 °C - closed cup
• Équipement de protection individuelle: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)