L5025

Leflunomide

Immunosuppressant

• Synonyme(s) : 5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilide
• Formule empirique (notation de Hill) : C₁₂H₉F₃N₂O₂
• CAS Number: 75706-12-6
• Poids moléculaire : 270.21
• Numéro MDL: MFCD00867593
• Code UNSPSC : 12352202
• ID de substance PubChem : 24278516
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: ≥98% (TLC)
• Forme: powder
• Pf: 166.5 °C
• Solubilité: methanol: 19.60-20.40 mg/mL, clear, colorless to faintly yellow
• Mode d’action: enzyme | inhibits
• Température de stockage: 2-8°C
• Chaîne SMILES: Cc1oncc1C(=O)Nc2ccc(cc2)C(F)(F)F
• InChI: 1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
• Clé InChI: VHOGYURTWQBHIL-UHFFFAOYSA-N
• Informations sur le gène: human ... DHODH(1723)

Description

Application

By virtue of its immunosuppressant effects, leflunomide has found use in organ transplantation and treatment of rheumatoid arthritis and other autoimmune diseases.

Actions biochimiques/physiologiques

Immunosuppressive; inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is believed to inhibit dihydroorotate dehydrogenase (in the de novo pyrimidine synthesis pathway) as well as several protein tyrosine kinases.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301,H315,H319,H335
• Conseils de prudence: P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves