L6292

Lisinopril

≥98% (HPLC)

• Synonyme(s) : (S)-1-[N2-(1-carboxy-3-phenylpropyl)-lysyl-proline dihydrate, MK-521
• Formule empirique (notation de Hill) : C₂₁H₃₁O₅N₃ · 2H₂O
• CAS Number: 83915-83-7
• Poids moléculaire : 441.52
• Numéro MDL: MFCD01698825
• Code UNSPSC : 12352200
• ID de substance PubChem : 329817636
• Nomenclature NACRES : NA.32

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Couleur: white
• Solubilité: H₂O: ≥10 mg/mL; DMSO: ~6.5 mg/mL (with heating and sonicating)
• Température de stockage: 2-8°C
• Chaîne SMILES: [H]O[H].[H]O[H].NCCCC[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N2CCC[C@H]2C(O)=O
• InChI: 1S/C21H31N3O5.2H2O/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15;;/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29);2*1H2/t16-,17-,18-;;/m0../s1
• Clé InChI: CZRQXSDBMCMPNJ-ZUIPZQNBSA-N
• Informations sur le gène: human ... ACE(1636)

Description

Application

Lisinopril has been used to study the antifibrotic effect in duchenne muscular dystrophy mice. It has been used to study the changes in renal-structure and -function in TGR(mRen2)27 (transgenic rat harboring the murine Ren-2 gene) rats upon long term darbepoetin α treatment.

Actions biochimiques/physiologiques

Angiotensin converting enzyme (ACE) inhibitor.

Caractéristiques et avantages

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H360D,H373
• Conseils de prudence: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Repr. 1A - STOT RE 2
• Organes cibles: Kidney
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)