C4042

Captopril

≥98% (HPLC), powder, angiotensin converting enzyme inhibitor

• Synonyme(s) : N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline
• Formule empirique (notation de Hill) : C₉H₁₅NO₃S
• CAS Number: 62571-86-2
• Poids moléculaire : 217.29
• Beilstein: 477887
• Numéro CE : 263-607-1
• Numéro MDL: MFCD00168073
• Code UNSPSC : 12352200
• ID de substance PubChem : 57654003
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Captopril, ≥98% (HPLC), powder
• Source biologique: synthetic
• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to off-white
• Pf: 104-108 °C (lit.)
• Solubilité: water: 100 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• Auteur: Bristol-Myers Squibb
• Température de stockage: room temp
• Chaîne SMILES: C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O
• InChI: 1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
• Clé InChI: FAKRSMQSSFJEIM-RQJHMYQMSA-N
• Informations sur le gène: human ... ACE(1636), AGTR1(185), AGTR2(186), ECE1(1889) ; rat ... Ace(24310)

Description

Application

Captopril has been used:

• to examine the influence of timing of captopril treatment on efficacy in transverse aortic constriction (TAC) mice
• as an angiotensin-converting enzyme inhibitor and orally administered to unrestrained Wistar Kyoto rats in an approach to study its effects of angiogenesis inhibition and interdependency with other drugs
• used as a positive control in spectrophotometric assay to study the angiotensin-converting enzyme inhibitory activity

Actions biochimiques/physiologiques

Angiotensin converting enzyme inhibitor. Inhibits the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.

Captopril is known to decrease the cardiovascular complications arising due to myocardial infarction. It is an effective drug in treating diabetic nephropathy and renal disease. Captopril acts by reducing cardiac related inflammation, fibrosis and calcification.

Caractéristiques et avantages

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H341,H360F
• Conseils de prudence: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Muta. 2 - Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges