M0567

Microsomes from Liver, Pooled

from human male

• Synonyme(s) : lab equipment accessory
• Code UNSPSC : 12352204
• Nomenclature NACRES : NA.54

Propriétés

• Source biologique: human male
• Niveau de qualité: 200
• Forme: liquid
• Conditionnement: vial of ~10 mg
• Conditions d'expédition: dry ice
• Température de stockage: −70°C

Description

Application

Microsomes from Liver, Pooled has been used:

• in the glucuronidation kinetics assay to test the effects of herbal extracts on glucuronidation process
• as a human liver microsomes (HLM) matrix for testing metabolic stability of talazoparib using liquid chromatography-tandem mass spectrometry (LC–MS/MS)
• to study the metabolization of enantiomeric peptide D3

Microsomes from liver have been used in a study to assess differences in enzymatic activities between normal rat livers and from liver after partial hepatectomy. They have also been used in a study to investigate the carbon monoxide-binding pigment in liver microsomes.

Actions biochimiques/physiologiques

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.

N-glucuronidation of various 1-substituted imidazoles was found to occur in human liver microsomes.

Source of drug metabolizing enzymes, including cytochrome P-450.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable