M9441

Microsomes from Liver, Pooled

from mouse(CD-1), male

• Synonyme(s) : lab equipment accessory
• Code UNSPSC : 12161501
• Nomenclature NACRES : NA.47

Propriétés

• Source biologique: mouse (CD-1)
• Niveau de qualité: 200
• Forme: liquid
• Conditionnement: vial of ~10 mg
• Numéro d'accès UniProt: Q91VS7
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Informations sur le gène: mouse ... Mgst1(56615)

Description

Description générale

Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).

Application

Microsomes from Liver, Pooled has been also been used to study the metabolic stability of antitumor agents and tunicamycin.

Microsomes from Liver, Pooled has been used in cell survival and mutation assays in Escherichia coli.

Actions biochimiques/physiologiques

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.

Microsomes might act as cell organelles and are actively involved in protein synthesis. Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids. Murine liver microsomes plays a crucial role in degradation of small antimicrobial β^2,2-amino acid derivatives.

Source of drug metabolizing enzymes, including cytochrome P-450.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable